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Systemic and regional haemodynamic interactions between K+ channel openers and the sympathetic nervous system in the pithed SHR.

机译：髓性SHR中K +通道开放剂和交感神经系统之间的系统性和区域性血流动力学相互作用。

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1. The interactions between two K+ channel openers, cromakalim and SR 44866 (infused i.v. at equihypotensive doses), and the sympathetic nervous system at the systemic and regional (mesentery, kidney, hindlimb) vascular levels were investigated in the pithed spontaneously hypertensive rat (SHR) by use of the pulsed Doppler technique. 2. The two K+ channel openers did not affect postsynaptic alpha 1- but slightly reduced postsynaptic alpha 2-adrenoceptor mediated systemic pressor and regional vasoconstrictor responses. 3. Both drugs significantly decreased the systemic pressor and regional vasoconstrictor responses elicited by spinal cord stimulation. These sympathoinhibitory effects were not homogeneously distributed among the different vascular beds, the decreasing rank order being: mesentery greater than kidney greater than hindlimb. Simultaneously, the spinal cord stimulation-induced tachycardia remained unaffected. 4. After treatment with K+ channel openers, restoration of initial blood pressure and vascular tone values by infusion of prostaglandin F2 alpha (PGF2 alpha) and vasopressin respectively did not affect and abolished the sympathoinhibitory effects of cromakalim and SR 44866. 5. We conclude that in SHRs the two K+ channel openers that we investigated exert similar sympathohibitory effects which affect some vascular beds more than others. These effects are not dependent upon the arterial blood pressure level and are most likely prejunctionally located.
机译：1.研究了自发性高血压大鼠的两个K +通道开放剂cromakalim和SR 44866（以等压剂量静脉输注）与全身和区域（肠系膜，肾，后肢）血管交感神经系统之间的相互作用（ SHR）通过使用脉冲多普勒技术。 2.两个K +通道开放剂不影响突触后α1，但使突触后α2肾上腺素受体介导的全身性升压和局部血管收缩反应略微降低。 3.两种药物均显着降低了脊髓刺激引起的全身性升压和局部血管收缩反应。这些交感神经抑制作用在不同的血管床之间分布不均匀，其降序顺序为：肠系膜大于肾脏，大于后肢。同时，脊髓刺激引起的心动过速保持不受影响。 4.用K +通道开放剂治疗后，分别注入前列腺素F2 alpha（PGF2 alpha）和加压素可恢复初始血压和血管紧张度值，但并未影响并消除了克罗马卡林和SR 44866的交感神经抑制作用。5.我们得出结论：在SHRs中，我们研究的两个K +通道开放剂具有相似的交感抑制作用，对某些血管床的影响大于其他血管床。这些影响不依赖于动脉血压水平，并且很可能位于结扎处。

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